Signaling Delays Preclude Defects in Lateral Inhibition Patterning.
نویسندگان
چکیده
Lateral inhibition represents a well-studied example of biology's ability to self-organize multicellular spatial patterns with single-cell precision. Despite established biochemical mechanisms for lateral inhibition (e.g., Delta-Notch), it remains unclear how cell-cell signaling delays inherent to these mechanisms affect patterning outcomes. We investigate a compact model of lateral inhibition highlighting these delays and find, remarkably, that long delays can ensure defect-free patterning. This effect is underscored by an interplay with synchronous oscillations, cis interactions, and signaling strength. Our results suggest that signaling delays, though previously posited as a source of developmental defects, may in fact be a general regulatory knob for tuning developmental robustness.
منابع مشابه
Abstract Submitted for the Mar15 Meeting of the American Physical Society Signaling Delays Preclude Defects in Lateral Inhibition Pattern
Submitted for the MAR15 Meeting of The American Physical Society Signaling Delays Preclude Defects in Lateral Inhibition Patterning INGMAR RIEDEL-KRUSE, DAVID GLASS, XIAOFAN JIN, Stanford University, Bioengineering — Developmental biology is extraordinarily robust in its ability to self-organize spatiotemporal patterns despite an intrinsically noisy set of parts. Lateral inhibition is a classic...
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ورودعنوان ژورنال:
- Physical review letters
دوره 116 12 شماره
صفحات -
تاریخ انتشار 2016